| Go West on East-West Expwy.(Some portions are toll) to Palmetto Expwy |
| Go South on Palmetto Expwy to South Dade Expwy |
| Go Southwest on South Dade Expwy(Some portions are toll) to Florida's Turnpike |
| Go Southwest on Florida's Turnpike(Some portions are toll) to US 1 |
| Go Southwest on US 1 |
| Upon reaching Key West continue on US 1 to Palm Avenue, turn right and take Palm Ave over bridge it turns into Eaton Street at the lights. Take Eaton Street to William Street and turn left, Key West Bed & Breakfast is on your left. |
